One-step microcapsules published in Science

The AQDOT technology has been published in Science.

Science 10 February 2012:
Vol. 335 no. 6069 pp. 690-694
DOI: 10.1126/science.1215416
One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets
Jing Zhang, Roger J. Coulston, Samuel T. Jones, Jin Geng, Oren A. Scherman, Chris Abell

Although many techniques exist for preparing microcapsules, it is still challenging to fabricate them in an efficient and scalable process without compromising functionality and encapsulation efficiency. We demonstrated a simple one-step approach that exploits a versatile host-guest system and uses microfluidic droplets to generate porous microcapsules with easily customizable functionality. The capsules comprise a polymer-gold nanoparticle composite held together by cucurbit[8]uril ternary complexes. The dynamic yet highly stable micrometer-sized structures can be loaded in one step during capsule formation and are amenable to on-demand encapsulant release. The internal chemical environment can be probed with surface enhanced Raman spectroscopy.

Received for publication 18 October 2011.

Accepted for publication 18 January 2012.

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